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Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation - Nature Immunology

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Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation - Nature Immunology

It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane pore-forming molecule that has been shown to execute pyroptotic cell death and thus to serve as a potential cancer checkpoint.

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Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation - Nature Immunology

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Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation - Nature Immunology

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