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Human DNA-dependent protein kinase activation mechanism - Nature Structural & Molecular Biology

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Human DNA-dependent protein kinase activation mechanism - Nature Structural & Molecular Biology

DNA-dependent protein kinase (DNA-PK), a multicomponent complex including the DNA-PK catalytic subunit and Ku70/80 heterodimer together with DNA, is central to human DNA damage response and repair. Using a DNA-PK-selective inhibitor (M3814), we identified from one dataset two cryo-EM structures of the human DNA-PK complex in different states, the intermediate state and the active state.

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Human DNA-dependent protein kinase activation mechanism - Nature Structural & Molecular Biology

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