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De novo genes with an lncRNA origin encode unique human brain developmental functionality - Nature Ecology & Evolution

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De novo genes with an lncRNA origin encode unique human brain developmental functionality - Nature Ecology & Evolution

Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how and why this all-or-nothing transition to functionality happens remains unclear. Here, in 74 human/hominoid-specific de novo genes, we identified distinctive U1 elements and RNA splice-related sequences accounting for RNA nuclear export, differentiating mRNAs from lncRNAs, and driving the origin of de novo genes from lncRNA loci.

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De novo genes with an lncRNA origin encode unique human brain developmental functionality - Nature Ecology & Evolution

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De novo genes with an lncRNA origin encode unique human brain developmental functionality - Nature Ecology & Evolution

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