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AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer - Oncogenesis

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AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer - Oncogenesis

Oncogenic activation of PI3K/AKT signaling pathway, together with epigenetic aberrations are the characters of castration-resistant prostate cancer (CRPC). UHRF1 as a key epigenetic regulator, plays a critical role in prostate cancer (PCa) development, and its expression is positively correlated with the degree of malignancy.

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AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer - Oncogenesis

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AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer - Oncogenesis

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Unlocking the Power of Knowledge
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