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Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells - Oncogene

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Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells - Oncogene

To understand how malignant tumors develop, we tracked cell membrane, nuclear membrane, spindle, and cell cycle dynamics in polyploid giant cancer cells (PGCCs) during the formation of high-grade serous carcinoma organoids using long-term time-lapse imaging. Single cells underwent traditional mitosis to generate tissue with uniform nuclear size, while others formed PGCCs via asymmetric mitosis, endoreplication, multipolar endomitosis, nuclear fusion, and karyokinesis without cytokinesis.

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Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells - Oncogene

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Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells - Oncogene

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