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Computational design of constitutively active cGAS - Nature Structural & Molecular Biology

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Computational design of constitutively active cGAS - Nature Structural & Molecular Biology

Cyclic GMP–AMP synthase (cGAS) is a pattern recognition receptor critical for the innate immune response to intracellular pathogens, DNA damage, tumorigenesis and senescence. Binding to double-stranded DNA (dsDNA) induces conformational changes in cGAS that activate the enzyme to produce 2′-3′ cyclic GMP–AMP (cGAMP), a second messenger that initiates a potent interferon (IFN) response through its receptor, STING.

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Computational design of constitutively active cGAS - Nature Structural & Molecular Biology

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Computational design of constitutively active cGAS - Nature Structural & Molecular Biology

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