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Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens - Nature Biotechnology

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Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens - Nature Biotechnology

Cancer neoantigens that arise from tumor mutations are drivers of tumor-specific T cell responses, but identification of T cell-recognized neoantigens in individual patients is challenging. Previous methods have restricted antigen discovery to selected HLA alleles, thereby limiting the breadth of neoantigen repertoires that can be uncovered.

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genetic neoantigens cell identification cd4 cd8 health cell biology biology microbiology

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Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens - Nature Biotechnology

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Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens - Nature Biotechnology

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