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High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2 | GLIS2 pediatric leukemia - Leukemia

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High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2 | GLIS2 pediatric leukemia - Leukemia

Pediatric acute myeloid leukemia expressing the ETO2 | GLIS2 fusion oncogene is associated with dismal prognosis. Previous studies have shown that ETO2 | GLIS2 can efficiently induce leukemia development associated with strong transcriptional changes but those amenable to pharmacological targeting remained to be identified.

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High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2 | GLIS2 pediatric leukemia - Leukemia

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High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2 | GLIS2 pediatric leukemia - Leukemia

Rate This Post

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Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
for Humanity's Progress