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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia - Leukemia

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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia - Leukemia

Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular differentiation and stem cell maintenance. Here we show NFIC protein is significantly overexpressed in 69% of acute myeloid leukemia patients. Examination of the functional consequences of NFIC overexpression in HSPCs showed that this protein promoted monocytic differentiation.

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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia - Leukemia

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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia - Leukemia

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