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R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response - Nature

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R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response - Nature

R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability1, which has been linked to the action of endonucleases such as XPG2–4. However, the mechanisms and cellular consequences of such processing have remained unclear. Here we identify a new population of RNA–DNA hybrids in the cytoplasm that are R-loop-processing products.

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R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response - Nature

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R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response - Nature

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