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3D vascularized eye tissue models age-related macular degeneration - Nature Methods

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3D vascularized eye tissue models age-related macular degeneration - Nature Methods

We engineered a 3D outer-blood-retina-barrier (3D-oBRB) with a fully polarized retinal pigment epithelium (RPE) monolayer on top of a Bruch's membrane and a fenestrated choriocapillaris network. This 3D-oBRB tissue faithfully recapitulates RPE– choriocapillaris interactions, dry age-related macular degeneration (AMD) phenotypes (including sub-RPE drusen deposits and choriocapillaris degeneration) and the wet AMD phenotype of choriocapillaris neovascularization.

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3D vascularized eye tissue models age-related macular degeneration - Nature Methods

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3D vascularized eye tissue models age-related macular degeneration - Nature Methods

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