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Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells - Nature Immunology

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Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells - Nature Immunology

The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of research, the roles of CD4–LCK and CD8–LCK interactions in TCR triggering in vivo remain unknown. In this study, we created animal models expressing endogenous levels of modified LCK to resolve whether and how co-receptor-bound LCK drives TCR signaling.

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Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells - Nature Immunology

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Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells - Nature Immunology

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