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Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice - Nature Metabolism

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Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice - Nature Metabolism

RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing factor RNA-binding Fox protein 2 (RBFOX2) in maintaining cholesterol homeostasis in a lipogenic environment in the liver.

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Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice - Nature Metabolism

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Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice - Nature Metabolism

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