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Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer - Nature Metabolism

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Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer - Nature Metabolism

The glycolytic enzyme lactate dehydrogenase A (LDHA) is frequently overexpressed in cancer, which promotes glycolysis and cancer. The oncogenic effect of LDHA has been attributed to its glycolytic enzyme activity. Here we report an unexpected noncanonical oncogenic mechanism of LDHA; LDHA activates small GTPase Rac1 to promote cancer independently of its glycolytic enzyme activity.

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Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer - Nature Metabolism

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Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer - Nature Metabolism

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