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Functional investigation of SLC1A2 variants associated with epilepsy - Cell Death & Disease

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Functional investigation of SLC1A2 variants associated with epilepsy - Cell Death & Disease

Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clearing extracellular accumulated glutamate. Previously, three variants (G82R, L85P, and P289R) in SLC1A2 (encoding GLT-1) have been clinically reported to be associated with epilepsy.

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Functional investigation of SLC1A2 variants associated with epilepsy - Cell Death & Disease

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Functional investigation of SLC1A2 variants associated with epilepsy - Cell Death & Disease

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