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Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain - Nature Aging

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Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain - Nature Aging

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific aging and rejuvenation. We generated single-cell transcriptomes from the subventricular zone neurogenic region of 28 mice, tiling ages from young to old. We trained single-cell-based regression models to predict chronological age and biological age (neural stem cell proliferation capacity).

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Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain - Nature Aging

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Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain - Nature Aging

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