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Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY - Nature Communications

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Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY - Nature Communications

The development of new antibacterial drugs with different mechanisms of action is urgently needed to address antimicrobial resistance. MraY is an essential membrane enzyme required for bacterial cell wall synthesis. Sphaerimicins are naturally occurring macrocyclic nucleoside inhibitors of MraY and are considered a promising target in antibacterial discovery. However, developing sphaerimicins as antibacterials has been challenging due to their complex macrocyclic structures.

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Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY - Nature Communications

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Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY - Nature Communications

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