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Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir - Nature Immunology

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Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir - Nature Immunology

Understanding the complexity of the long-lived HIV reservoir during antiretroviral therapy (ART) remains a considerable impediment in research towards a cure for HIV. To address this, we developed a single-cell strategy to precisely define the unperturbed peripheral blood HIV-infected memory CD4+ T cell reservoir from ART-treated people living with HIV (ART-PLWH) via the presence of integrated accessible proviral DNA in concert with epigenetic and cell surface protein profiling.

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Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir - Nature Immunology

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Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir - Nature Immunology

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