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STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression - British Journal of Cancer

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STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression - British Journal of Cancer

Deregulation of either RNA polymerase I (Pol I)-directed transcription or expression of signal transducer and activator of transcription 3 (STAT3) correlates closely with tumorigenesis. However, the connection between STAT3 and Pol I-directed transcription hasn't been investigated. The role of STAT3 in Pol I-directed transcription was determined using combined techniques. The regulation of tumor cell growth mediated by STAT3 and Pol I products was analyzed in vitro and in vivo.

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STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression - British Journal of Cancer

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STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression - British Journal of Cancer

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