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1 year ago

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IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine

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IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine

Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to IL7. We found that rs16906115 forms a B cell-specific expression quantitative trait locus (eQTL) to IL7 in patients.

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IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine

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IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine

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