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Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer - Oncogene

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Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer - Oncogene

Non-coding RNAs have an integral regulatory role in numerous functions related to lung cancer development. Here, we report identification of a novel lncRNA, termed TP53-inhibiting lncRNA (TILR), which was found to function as a constitutive negative regulator of p53 expression, including activation of downstream genes such as p21 and MDM2, and induction of apoptosis.

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Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer - Oncogene

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Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer - Oncogene

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
for Humanity's Progress