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Rational combinations of targeted cancer therapies: background, advances and challenges - Nature Reviews Drug Discovery

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Rational combinations of targeted cancer therapies: background, advances and challenges - Nature Reviews Drug Discovery

Over the past two decades, elucidation of the genetic defects that underlie cancer has resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be highly effective, resistance to single-agent therapies remains a major challenge. Combining drugs can help avoid resistance, but the number of possible drug combinations vastly exceeds what can be tested clinically, both financially and in terms of patient availability.

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Rational combinations of targeted cancer therapies: background, advances and challenges - Nature Reviews Drug Discovery

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Rational combinations of targeted cancer therapies: background, advances and challenges - Nature Reviews Drug Discovery

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