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Ovarian cancer mutational processes drive site-specific immune evasion - Nature

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Ovarian cancer mutational processes drive site-specific immune evasion - Nature

High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability1–4 patterned by distinct mutational processes5,6, tumour heterogeneity7–9 and intraperitoneal spread7,8,10. Immunotherapies have had limited efficacy in HGSOC11–13, highlighting an unmet need to assess how mutational processes and the anatomical sites of tumour foci determine the immunological states of the tumour microenvironment.

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Ovarian cancer mutational processes drive site-specific immune evasion - Nature

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Ovarian cancer mutational processes drive site-specific immune evasion - Nature

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