@curator

1 year ago

Article

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression - Cell Death & Disease

Rating: 0.0

Likes: 1

Library: 1

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression - Cell Death & Disease

Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small molecule BET inhibitors (BETi). With the aim of developing rational combination treatments for glioblastoma, we analyzed BETi-induced differential gene expression in glioblastoma derived-spheres, and identified 6 distinct response patterns.

Rate This Post

Rate The Educational Value

Rate The Ease of Understanding and Presentation

Interesting or Boring? Rate the Entertainment Value

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression - Cell Death & Disease

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge
for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge
for Humanity's Progress

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression - Cell Death & Disease

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress