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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts - Cellular & Molecular Immunology

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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts - Cellular & Molecular Immunology

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from the monocyte/macrophage lineage in response to receptor activator of NF-κB ligand (RANKL). However, the epigenetic signature contributing to the fate commitment of monocyte/macrophage lineage differentiation into human osteoclasts is largely unknown.

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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts - Cellular & Molecular Immunology

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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts - Cellular & Molecular Immunology

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