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1 year ago

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An ectopic enhancer restores CFTR expression through de novo chromatin looping - Gene Therapy

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An ectopic enhancer restores CFTR expression through de novo chromatin looping - Gene Therapy

Transcription of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is regulated by both ubiquitous and cell-type selective cis-regulatory elements (CREs). These CREs include extragenic and intronic enhancers that bind lineage-specific transcription factors, and architectural protein-marked structural elements.

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cftr enhancer expression ectopic de novo chromatin

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An ectopic enhancer restores CFTR expression through de novo chromatin looping - Gene Therapy

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An ectopic enhancer restores CFTR expression through de novo chromatin looping - Gene Therapy

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