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Extensive proteome and functional genomic profiling of variability between genetically identical human B-lymphoblastoid cells - Scientific Data
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In life-science research isogenic B-lymphoblastoid cell lines (LCLs) are widely known and preferred for their genetic stability – they are often used for studying mutations for example, where genetic stability is crucial. We have shown previously that phenotypic variability can be observed in isogenic B-lymphoblastoid cell lines. Isogenic LCLs present well-defined phenotypic differences on various levels, for example on the gene expression level or the chromatin level.
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