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Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens - Nature Communications

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Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens - Nature Communications

The development of cancer therapies is limited by the availability of suitable drug targets. Potential candidate drug targets can be identified based on the concept of synthetic lethality (SL), which refers to pairs of genes for which an aberration in either gene alone is non-lethal, but co-occurrence of the aberrations is lethal to the cell. Here, we present SLIdR (Synthetic Lethal Identification in R), a statistical framework for identifying SL pairs from large-scale perturbation screens.

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Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens - Nature Communications

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Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens - Nature Communications

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