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SHP1 loss augments DLBCL cellular response to ibrutinib: a candidate predictive biomarker - Oncogene

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SHP1 loss augments DLBCL cellular response to ibrutinib: a candidate predictive biomarker - Oncogene

SHP1, a tyrosine phosphatase, negatively regulates B-cell receptor (BCR) signaling. Ibrutinib selectively inhibits BTK and has been approved for the treatment of several types of B-cell lymphomas, but not yet in diffuse large B-cell lymphoma (DLBCL). A phase 3 clinical trial of ibrutinib–containing regimen has been completed to evaluate its activity in subtypes or subsets of DLBCL patients.

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SHP1 loss augments DLBCL cellular response to ibrutinib: a candidate predictive biomarker - Oncogene

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SHP1 loss augments DLBCL cellular response to ibrutinib: a candidate predictive biomarker - Oncogene

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