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Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction - Nature Communications

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Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction - Nature Communications

After myocardial infarction the innate immune response is pivotal in clearing of tissue debris as well as scar formation, but exaggerated cytokine and chemokine secretion with subsequent leukocyte infiltration also leads to further tissue damage. Here, we address the value of targeting a previously unknown a disintegrin and metalloprotease 10 (ADAM10)/CX3CL1 axis in the regulation of neutrophil recruitment early after MI.

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Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction - Nature Communications

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Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction - Nature Communications

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