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Structural variants drive context-dependent oncogene activation in cancer - Nature

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Structural variants drive context-dependent oncogene activation in cancer - Nature

Higher-order chromatin structure is important for the regulation of genes by distal regulatory sequences1,2. Structural variants (SVs) that alter three-dimensional (3D) genome organization can lead to enhancer–promoter rewiring and human disease, particularly in the context of cancer3. However, only a small minority of SVs are associated with altered gene expression4,5, and it remains unclear why certain SVs lead to changes in distal gene expression and others do not.

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Structural variants drive context-dependent oncogene activation in cancer - Nature

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Structural variants drive context-dependent oncogene activation in cancer - Nature

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