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Current challenges in understanding the role of enhancers in disease - Nature Structural & Molecular Biology

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Current challenges in understanding the role of enhancers in disease - Nature Structural & Molecular Biology

Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing evidence that enhancer dysfunction due to genetic, structural or epigenetic mechanisms contributes to a broad range of human diseases referred to as enhanceropathies.

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Current challenges in understanding the role of enhancers in disease - Nature Structural & Molecular Biology

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Current challenges in understanding the role of enhancers in disease - Nature Structural & Molecular Biology

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