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Conserved degronome features governing quality control associated proteolysis - Nature Communications

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Conserved degronome features governing quality control associated proteolysis - Nature Communications

The eukaryotic proteome undergoes constant surveillance by quality control systems that either sequester, refold, or eliminate aberrant proteins by ubiquitin-dependent mechanisms. Ubiquitin-conjugation necessitates the recognition of degradation determinants, termed degrons, by their cognate E3 ubiquitin-protein ligases. To learn about the distinctive properties of quality control degrons, we performed an unbiased peptidome stability screen in yeast.

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Conserved degronome features governing quality control associated proteolysis - Nature Communications

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Conserved degronome features governing quality control associated proteolysis - Nature Communications

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