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USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP - Cell Death & Disease

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USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP - Cell Death & Disease

Esophageal squamous carcinoma (ESCC) is the major subtype of esophageal cancer in China, accounting for 90% of cases. Recent studies revealed that abnormalities in the Hippo/YAP axis are pervasive in ESCC and are recognized as the important driver of ESCC progression. Since the activity of Hippo signaling is controlled by phosphorylation cascade, it is a mystery why the major effector YAP is still over-activated when the cascade is inhibited.

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USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP - Cell Death & Disease

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USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP - Cell Death & Disease

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