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Polarity of the CRISPR roadblock to transcription - Nature Structural & Molecular Biology

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Polarity of the CRISPR roadblock to transcription - Nature Structural & Molecular Biology

CRISPR (clustered regularly interspaced short palindromic repeats) utility relies on a stable Cas effector complex binding to its target site. However, a Cas complex bound to DNA may be removed by motor proteins carrying out host processes and the mechanism governing this removal remains unclear. Intriguingly, during CRISPR interference, RNA polymerase (RNAP) progression is only fully blocked by a bound endonuclease-deficient Cas (dCas) from the protospacer adjacent motif (PAM)-proximal side.

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Polarity of the CRISPR roadblock to transcription - Nature Structural & Molecular Biology

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