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Backbone amides are determinants of Cl− selectivity in CLC ion channels - Nature Communications

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Backbone amides are determinants of Cl− selectivity in CLC ion channels - Nature Communications

Chloride homeostasis is regulated in all cellular compartments. CLC-type channels selectively transport Cl− across biological membranes. It is proposed that side-chains of pore-lining residues determine Cl− selectivity in CLC-type channels, but their spatial orientation and contributions to selectivity are not conserved. This suggests a possible role for mainchain amides in selectivity.

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Backbone amides are determinants of Cl− selectivity in CLC ion channels - Nature Communications

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Backbone amides are determinants of Cl− selectivity in CLC ion channels - Nature Communications

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