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Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern - Nature Immunology
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We isolated CD4+ T cell clones from healthcare workers infected with SARS-CoV-2 during the first COVID-19 wave and identified 21 epitopes across three viral proteins: spike, membrane and nucleoprotein. Focusing on spike protein, for seven of ten epitopes mutated in variants of concern, we found that T cell recognition was impaired.
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