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Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles - Nature Immunology

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Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles - Nature Immunology

Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic and can injure cellular longevity. Here we show that CD8+ memory T (TM) cells mobilize the carbamoyl phosphate (CP) metabolic pathway to clear ammonia, thus promoting memory development. CD8+ TM cells use β-hydroxybutyrylation to upregulate CP synthetase 1 and trigger the CP metabolic cascade to form arginine in the cytosol.

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urea cell ammonia cd8 memory citrulline cell biology biology microbiology

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Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles - Nature Immunology

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Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles - Nature Immunology

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