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DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury - Cell Death & Differentiation

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DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury - Cell Death & Differentiation

Hallmark pathological features of brain trauma are axonal degeneration and demyelination because myelin-producing oligodendrocytes (OLs) are particularly vulnerable to injury-induced death signals. To reveal mechanisms responsible for this OL loss, we examined a novel class of “death receptors” called dependence receptors (DepRs). DepRs initiate pro-death signals in the absence of their respective ligand(s), yet little is known about their role after injury.

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DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury - Cell Death & Differentiation

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DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury - Cell Death & Differentiation

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