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PLD3 affects axonal spheroids and network defects in Alzheimer's disease - Nature

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PLD3 affects axonal spheroids and network defects in Alzheimer's disease - Nature

The precise mechanisms that lead to cognitive decline in Alzheimer's disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction. Using intravital calcium and voltage imaging, we show that a mouse model of Alzheimer's disease demonstrates severe disruption in long-range axonal connectivity.

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PLD3 affects axonal spheroids and network defects in Alzheimer's disease - Nature

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PLD3 affects axonal spheroids and network defects in Alzheimer's disease - Nature

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