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Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity - Nature Communications

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Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity - Nature Communications

Recent studies have shown that G protein coupled receptors (GPCRs) show selective and promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the range of coupling preferences remain unclear. Here, we use Molecular Dynamics (MD) simulations on ten GPCR:G protein complexes and show that the location (spatial) and duration (temporal) of intermolecular contacts at the GPCR:Gα protein interface play a critical role in how GPCRs selectively interact with G proteins.

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Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity - Nature Communications

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Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity - Nature Communications

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