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Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis - Nature Immunology

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Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis - Nature Immunology

Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate immune memory can develop via a local inflammatory pathway following mucosal exposure. However, whether mucosal-resident innate memory results from integrating distally generated immunological signals following parenteral vaccination/infection is unclear.

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Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis - Nature Immunology

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Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis - Nature Immunology

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