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Metabolon formation regulates branched-chain amino acid oxidation and homeostasis - Nature Metabolism

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Metabolon formation regulates branched-chain amino acid oxidation and homeostasis - Nature Metabolism

The branched-chain aminotransferase isozymes BCAT1 and BCAT2, segregated into distinct subcellular compartments and tissues, initiate the catabolism of branched-chain amino acids (BCAAs). However, whether and how BCAT isozymes cooperate with downstream enzymes to control BCAA homeostasis in an intact organism remains largely unknown. Here, we analyse system-wide metabolomic changes in BCAT1- and BCAT2-deficient mouse models.

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Metabolon formation regulates branched-chain amino acid oxidation and homeostasis - Nature Metabolism

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Metabolon formation regulates branched-chain amino acid oxidation and homeostasis - Nature Metabolism

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