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Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency - International Journal of Oral Science

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Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency - International Journal of Oral Science

As an important enzyme for gluconeogenesis, mitochondrial phosphoenolpyruvate carboxykinase (PCK2) has further complex functions beyond regulation of glucose metabolism. Here, we report that conditional knockout of Pck2 in osteoblasts results in a pathological phenotype manifested as craniofacial malformation, long bone loss, and marrow adipocyte accumulation. Ablation of Pck2 alters the metabolic pathways of developing bone, particularly fatty acid metabolism.

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Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency - International Journal of Oral Science

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Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency - International Journal of Oral Science

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