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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila - Cell Death & Disease

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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila - Cell Death & Disease

The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human GOLPH3 correlates with poor prognosis in several cancer types and is associated with enhanced signaling downstream of mTOR (mechanistic target of rapamycin). However, the molecular link between GOLPH3 and mTOR remains elusive.

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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila - Cell Death & Disease

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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila - Cell Death & Disease

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