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Death by TNF: a road to inflammation - Nature Reviews Immunology

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Death by TNF: a road to inflammation - Nature Reviews Immunology

Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies. In recent years, it became clear that TNF drives inflammatory responses not only directly by inducing inflammatory gene expression but also indirectly by inducing cell death, instigating inflammatory immune reactions and disease development.

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Death by TNF: a road to inflammation - Nature Reviews Immunology

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Death by TNF: a road to inflammation - Nature Reviews Immunology

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