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Glutamatergic synapse in autism: a complex story for a complex disorder - Molecular Psychiatry

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Glutamatergic synapse in autism: a complex story for a complex disorder - Molecular Psychiatry

Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathophysiological mechanisms are still unclear. Hypotheses suggest a role for glutamate dysfunctions in ASD development, but clinical studies investigating brain and peripheral glutamate levels showed heterogenous results leading to hypo- and hyper-glutamatergic hypotheses of ASD. Recently, studies proposed the implication of elevated mGluR5 densities in brain areas in the pathophysiology of ASD.

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Glutamatergic synapse in autism: a complex story for a complex disorder - Molecular Psychiatry

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Glutamatergic synapse in autism: a complex story for a complex disorder - Molecular Psychiatry

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