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Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice - npj Parkinson's Disease

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Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice - npj Parkinson's Disease

Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression. Mutations of mitochondrial E3 ligase, PARKIN, have been associated with juvenile PD. Previous studies have characterized muscle atrophy and motor deficits upon loss of functional Parkin in fly and rodent models. However, the mechanisms behind pathophysiology of Parkin deficient muscle remains to be elusive.

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Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice - npj Parkinson's Disease

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Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice - npj Parkinson's Disease

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