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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C - Cell Death & Differentiation

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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C - Cell Death & Differentiation

How BAK and BAX induce mitochondrial outer membrane (MOM) permeabilization (MOMP) during apoptosis is incompletely understood. Here we have used molecular dynamics simulations, surface plasmon resonance, and assays for membrane permeabilization in vitro and in vivo to assess the structure and function of selected BAK subdomains and their derivatives. Results of these studies demonstrate that BAK helical regions α5 and α6 bind the MOM lipid cardiolipin.

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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C - Cell Death & Differentiation

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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C - Cell Death & Differentiation

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