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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis - Nature Cancer

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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis - Nature Cancer

Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells.

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cancer cells cancer senescent cells dr5 activation suppression sensitize health cell biology biology microbiology

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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis - Nature Cancer

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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis - Nature Cancer

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